Publikationen
Ausgewählte PUBLIkationen· Gruber S, Löf A, Hausch A, Kutzki F, Jöhr R, Obser T, König G, Schneppenheim R, Aponte-Santamaría C, Gräter F, Brehm MA, Benoit M, Lipfert J. “A conformational transition of the D'D3 domain primes von Willebrand factor for multimerization”. Blood Adv. 2022 Sep 13;6(17):5198-5209. doi: 10.1182/bloodadvances.2022006978.
· Huck V, Chen PC, Xu ER, Tischer A, Klemm U, Aponte-Santamaría C, Mess C, Obser T, Kutzki F, König G, Denis CV, Gräter F, Wilmanns M, Auton M, Schneider SW, Schneppenheim R, Hennig J, Brehm MA. “Gain-of-Function Variant p.Pro2555Arg of Von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics”. Thromb Haemost. 2022 Feb;122(2):226-239. doi: 10.1055/a-1344-4405. Epub 2021 Apr 14.
· Robador JR, Feinauer MJ, Schneider SW, Mayer FT, Gorzelanny C, Sacharow A, Liu X, Berghoff A, Brehm MA, Hirsch D, Stadler J, Vidal-Y-Si S, Wladykowski E, Asong M, Nowak K, Seiz-Rosenhagen M, Umansky V, Mess C, Pantel K, Winkler F, Bauer AT. “Involvement of platelet-derived VWF in metastatic growth of melanoma in the brain”. Neurooncol Adv. 2021 Nov 22;3(1):vdab175. doi: 10.1093/noajnl/vdab175. eCollection 2021 Jan-Dec.
· Sandoval-Pérez A, Berger R, Brehm MA, König G, Schneider SW, Huck V, Rädler JO, Aponte-Santamaría C. „DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions”, Nucleic Acids Research. 2020 https://doi.org/10.1093/nar/gkaa466.
· Letzer A, Lehmann K, König G, Obser T, Schneppenheim S, Budde U, Schneppenheim S, Brehm MA, „Upshaw-Schulman syndrome-associated ADAMTS13 variants possess proteolytic activity at the surface of endothelial cells and in simulated circulation”, PLoS One. 2020 May 4;15(5):e0232637
· Tischer A, Brehm MA, Machha VR, Moon-Tasson L, Benson LM, Nelton KJ, Leger RR, Obser T, Martinez-Vargas M, Steven T. Whitten ST, Chen D, Pruthi RK, Bergen III HR, Cruz MA, Schneppenheim R, Auton M, “Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease”, J Mol Biol. 2020 Jan 17;432(2):305-323.
· Löf A, Walker PU, Sedlak SM, Obser T, Brehm MA, Benoit M, Lipfert J, “Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor”, Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18798-18807.
· König G, Obser T, Marggraf O, Schneppenheim S, Budde U, Schneppenheim R, Brehm MA. „Alteration in GPIIb/IIIa binding of VWD-associated von Willebrand factor variants with C-terminal missense mutations”, Thromb. Haemost. 2019, Jul;119(7):1102-1111.
· Jagau H, Behrens IK, Elspaß V, Lahme K, Lorz G, Köster RW, Schneppenheim R, Obser T, Brehm MA, König G, Rohde M, Kohler TP, Hammerschmidt S, Frank R, Tegge W, Fulde M, Steinert M, Bergmann S, “Von Willebrand Factor mediates pneumococcal aggregation and adhesion in blood flow via surface-displayed enolase”, Frontiers Microbiology. 2019, Mar 26;10:511.
· Löf A, König G, Schneppenheim S, Schneppenheim R, Benoit M, Budde U, Müller JP, Brehm MA, “Advancing multimer analysis of von Willebrand factor by single-molecule AFM imaging” PLoS One, 2019 Jan 15;14(1):e0210963.
· Brehm MA, Klemm U, Rehbach C, Erdmann N, Kolšek K, Lin H, Aponte-Santamaría C, Gräter F, Rauch BH, Riley AM, Mayr GW, Potter BVL, Windhorst S, „Inositol hexakisphosphate increases the size of platelet aggregates”, Biochem Pharmacol. 2019 Mar;161:14-25.
· Schneppenheim R, Hellermann N, Brehm MA, Klemm U, Obser T, Huck V, Schneider SW, Denis CV, Tischer A, Auton M, März W, Xu ER, Wilmanns M, Zotz RB, “The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction” Blood. 2019 Jan 24;133(4):356-365.
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