Prof. of Biotechnology - Working Group Endothelial Dynamics and Coagulation

We investigate the molecular, cellular and biomechanical mechanisms that regulate the complex interactions between blood flow, platelets, endothelium and coagulation. Our central interest is how mechanical forces and endothelial signaling pathways control vascular homeostasis and how their dysregulation contributes to the development of thrombotic diseases, coagulation disorders and vascular remodeling disorders.

A major focus of our research is the mechanosensitive regulation of hemostasis. In particular, we analyze the role of the von Willebrand factor, the protease ADAMTS13 and platelet activation under defined shear conditions. We investigate how blood flow, endothelial permeability and endothelial-platelet interactions influence the initiation and stabilization of thrombi and how disturbances of these processes lead to various clinical pictures.

In addition, we investigate endothelial signaling pathways that regulate new vessel formation. A particular focus is on the pathogenesis of angiodysplasia in the context of von Willebrand syndrome, in which dysregulation of angiogenic signaling pathways, endothelial integrity and hemostasis are closely linked.

Methodologically, the group combines cell and molecular biology approaches with physiologically relevant flow and microfluidic systems, including organ-on-a-chip and especially gut-on-a-chip models, to study the interaction of endothelium, epithelium, blood components and mechanical forces in controlled environments. These approaches are complemented by functional coagulation analyses and biophysical methods. The aim of our work is to decipher basic mechanisms of endothelial dynamics and blood coagulation and to translate these findings into innovative diagnostic and therapeutic strategies for vascular and thrombotic diseases.